Detalhe da pesquisa
1.
Cross-class metallo-ß-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
Proc Natl Acad Sci U S A
; 113(26): E3745-54, 2016 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27303030
2.
Cyclobutanone Mimics of Intermediates in Metallo-ß-Lactamase Catalysis.
Chemistry
; 24(22): 5734-5737, 2018 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29250863
3.
Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-ß-lactamases.
Biochemistry
; 54(20): 3183-96, 2015 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25915520
4.
7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent.
Bioorg Med Chem Lett
; 25(19): 4203-9, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26296477
5.
N-(4-Substituted-benzoyl)-N'-(ß-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
Bioorg Med Chem
; 20(5): 1801-16, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22325154
6.
Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design.
Biochem J
; 427(1): 19-28, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20067443
7.
Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells.
Bioorg Med Chem Lett
; 20(20): 5988-93, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20833547
8.
Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-ß-lactamases.
FEBS J
; 286(1): 169-183, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30430727
9.
Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site.
Protein Sci
; 14(4): 873-88, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15741340
10.
Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs.
Protein Sci
; 14(7): 1760-71, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15987904
11.
Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution.
Biochim Biophys Acta
; 1647(1-2): 325-32, 2003 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12686153
12.
Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes.
J Med Chem
; 48(20): 6178-93, 2005 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190745
13.
Crystal Structure of DIM-1, an Acquired Subclass B1 Metallo-ß-Lactamase from Pseudomonas stutzeri.
PLoS One
; 10(10): e0140059, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26451836
14.
Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase.
ACS Infect Dis
; 1(11): 544-54, 2015 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27623409
15.
High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors.
Protein Sci
; 12(11): 2559-74, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-14573867
16.
Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.
J Med Chem
; 56(22): 9122-35, 2013 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24195668
17.
Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.
J Med Chem
; 55(20): 8721-34, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23043539
18.
Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.
J Med Chem
; 53(14): 5213-28, 2010 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20565112
19.
Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site.
Bioorg Med Chem
; 14(23): 7835-45, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16908161
20.
Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase.
Bioorg Med Chem
; 14(1): 181-9, 2006 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16213146